Acomplia (Rimonabant) – Investigational Agent for the Management of Obesity
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Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity. It works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endogenous cannabinoids, such as anadamide, increases appetite.
Although available in Europe since 2006 for use as an adjunct to diet and exercise for obese or overweight patients with associated risk factors.
In October 2008, following a review of post-marketing data, the EMEA recommended suspension of the drug’s marketing authorisation on safety grounds. Data had shown a doubling of the risk of psychiatric disorders in patients taking Acomplia in comparison with placebo.
Obesity predisposes to serious illness
Obesity is now the most common nutritional disorder in western industrialised countries. Defined as a body mass index of greater than 30, it arises from the accumulation of excess fat in the body from over consumption of fatty foods.
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